Crossword Genius

Refuse to remain with enterprise (3-2-3-2)

Ross

I believe the answer is:

get-up-and-go

I'm a little stuck... Click here to teach me more about this clue!

'enterprise' is the definition.
(I've seen this before)

'refuse to remain with' is the wordplay.
I cannot quite understand how this works, but
'with' could be 'and' and 'and' is present in the answer.
This may be the basis of the clue (or it may be nonsense).

Can you help me to learn more?

(Other definitions for get-up-and-go that I've seen before include "'pizazz'" , "Vim" .)

I've seen this clue in The Independent.
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