.... Reg Cole, disturbed master painter (2,5)
I believe the answer is:
el greco
'master painter' is the definition.
'el greco' can be an answer for 'painter' (nickname of Domenikos Theotokpoulos, 1541-1641). I'm unsure of the 'master' bit.
'reg cole disturbed' is the wordplay.
'disturbed' indicates anagramming the letters (the order of letters is disturbed).
'reg'+'cole'='regcole'
'regcole' is an anagram of 'EL GRECO'.
Can you help me to learn more?
(Other definitions for el greco that I've seen before include "Sp. painter, born Domen- ikos Theotokopoulos" , "Spanish painter, nicknamed for his place of birth" , "Spanish Renaissance painter" , "Cretan-born Spanish painter, d. 1614" , "Crete-born Sp. painter" .)