Released to use handle differently (9)
I believe the answer is:
unleashed
'released' is the definition.
(unleashing is a kind of releasing)
'use handle differently' is the wordplay.
'differently' is an anagram indicator.
'use'+'handle'='usehandle'
'usehandle' is an anagram of 'UNLEASHED'.
'to' acts as a link.
(Other definitions for unleashed that I've seen before include "let go" , "Freed from restraint" , "Let loose" .)