Reprobate in small hotel with royal (6)
I believe the answer is:
sinner
'reprobate' is the definition.
(I've seen this in another clue)
'small hotel with royal' is the wordplay.
'small' becomes 's' (abbreviation - e.g. clothes size).
'hotel' becomes 'inn' (inn is a kind of hotel).
'with' is a charade indicator (letters next to each other).
'royal' becomes 'er' (abbreviation for Elizabeth Regina).
's'+'inn'+'er'='SINNER'
'in' is the link.
(Other definitions for sinner that I've seen before include "Evildoer" , "Wrong-doer" , "Person straying" , "Miscreant" , "Serious offender" .)