Resident is at home with his wife (6)
I believe the answer is:
inmate
'resident' is the definition.
(I know that inmate is a type of resident)
'at home with his wife' is the wordplay.
'at home' becomes 'in' (similar in meaning).
'with' is a charade indicator (letters next to each other).
'his wife' becomes 'mate' (I've seen this in other clues).
'in'+'mate'='INMATE'
'is' is the link.
(Other definitions for inmate that I've seen before include "Inhabitant of prison or hospital" , "eg Prisoner" , "One is in jail" , "Person serving a jail sentence" , "Institution resident" .)