Resolution of labour issue, largely beneficial (10)
I believe the answer is:
salubrious
'beneficial' is the definition.
(thesaurus)
'resolution of labour issue largely' is the wordplay.
'resolution of' indicates anagramming the letters (I've seen 'resolution' mean this).
'largely' means to remove the last letter.
'labour'+'issue'='labourissue'
'labourissue' with its last letter taken away is 'labourissu'.
'labourissu' is an anagram of 'SALUBRIOUS'.
(Other definitions for salubrious that I've seen before include "Health-giving; (of a place) not run-down" , "good for you" , "Wholesome, healthy" .)