Retaliation of noble time and time again on course (13)
I believe the answer is:
counterattack
'retaliation' is the definition.
(to retaliate is to hit back)
'noble time and time again on course' is the wordplay.
I cannot quite understand how this works, but
'noble' could be 'count' (count is a kind of noble) and 'count' is found in the answer.
'time' could be 'era' (era is a kind of time) and 'era' is found within the answer.
'course' could be 'tack' (I've seen this before) and 'tack' is found within the answer.
A single letter 't' remains which might be clued in a way I don't understand.
This explanation may well be incorrect...
'of' acts as a link.
(Other definitions for counterattack that I've seen before include "Responsive onslaught" , "Onslaught in response" , "Retaliatory action" , "Riposte to an offensive" , "Fight back" .)