Run a profession (6)
I believe the answer is:
career
I believe this is a double definition.
'run' is the first definition.
(thesaurus)
'a profession' is the second definition.
(someone's profession is their career or occupation)
(Other definitions for career that I've seen before include "Run - profession" , "Progress through profession" , "Not intellectual" , "Life's occupation" , "Life (in terms of work etc)" .)