Run with difficulty? (6)

I believe the answer is:

manage

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'run' is the definition.
(run can mean to manage or be in charge of)

I don't understand the rest of the clue.

(Other definitions for manage that I've seen before include "Handle, cope with" , "Run (eg, company)" , "Run (a football team)" , "Organise" , "Take control" .)

I've seen this clue in the Evening Standard.

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