Sack female over anger (4)
I believe the answer is:
fire
'sack' is the definition.
('fire' can be a synonym of 'sack')
'female over anger' is the wordplay.
'female' becomes 'f' (abbreviation).
'over' is a charade indicator (letters next to each other).
'anger' becomes 'ire' ('ire' can be a synonym of 'anger').
'f'+'ire'='FIRE'
(Other definitions for fire that I've seen before include "Weaponry" , "Manually operated device for dealing with flames" , "Blaze - discharge" , "Ready, aim . . . ." , "Shoot; sack" .)