Sail out of port (5)
I believe the answer is:
genoa
I believe this clue is a double definition.
'sail' is the first definition.
(I've seen this before)
'port' is the second definition.
(I've seen this before)
'out of' acts as a link.
(Other definitions for genoa that I've seen before include "Cake type; foresail" , "North Italian port" , "Italian city; sail" , "Seaport in northwestern Italy" , "Italian city has no age, oddly" .)