Satisfy publican's initial tenancy agreement (6)
I believe the answer is:
please
'satisfy' is the definition.
(I know this)
'publican's initial tenancy agreement' is the wordplay.
'initial' indicates taking the first letters.
'tenancy agreement' becomes 'lease' (agreement for leasing a property).
The first letter of 'publicans' is 'p'.
'p'+'lease'='PLEASE'
(Other definitions for please that I've seen before include "If you'd be so kind?" , "Polite addition to a request" , "Want" , "See pal (anag) -- charm" , "Polite request - make someone happy" .)