Second person no longer still ignores Grand Hotel (4)
I believe the answer is:
thou
'second person no longer' is the definition.
('thou' is an archaic second person pronoun)
I can't explain the remainder of the clue.
(Other definitions for thou that I've seen before include "Subject" , "You (archaic, but still used in prayers)" , "You (arch.)" , "You (many years ago)" , "once paired with art" .)