See and sign new book (7)
I believe the answer is:
genesis
'book' is the definition.
(first book of the Bible)
'see and sign new' is the wordplay.
'and' says to put letters next to each other.
'new' is an anagram indicator.
'see' put after 'sign' is 'signsee'.
'signsee' with letters rearranged gives 'GENESIS'.
(Other definitions for genesis that I've seen before include "Beginning (in the Bible)" , "OT opening" , "Beginning the holy book" , "Creation" , "Origin; Bible book" .)