Set a new course? (4)
I believe the answer is:
east
'course?' is the definition.
(I've seen this before)
'set a new' is the wordplay.
'new' is an anagram indicator.
'set'+'a'='seta'
'seta' with letters rearranged gives 'EAST'.
(Other definitions for east that I've seen before include "One regularly holding hands" , "Direction taken when going from the US towards Ireland" , "Direction of the Orient" , "Compass direction" , "Airport near Derby" .)