Severe, twisted features ignored by female (7)
I believe the answer is:
austere
'severe' is the definition.
(synonyms)
'twisted features ignored by female' is the wordplay.
'twisted' indicates an anagram.
'ignored by' is a deletion indicator.
'female' becomes 'f' (common abbreviation).
'features' with 'f' removed is 'eatures'.
'eatures' is an anagram of 'AUSTERE'.
(Other definitions for austere that I've seen before include "Grim - USA tree (anag)" , "Bleak" , "Abstemious, strict" , "Lacking adornments" , "Stark" .)