She can give one a hand-out (5)
I believe the answer is:
dinah
'she' is the definition.
'give one a hand-out' is the wordplay.
'give' means one lot of letters go next to another.
'one' becomes 'I' (Roman numeral).
'out' indicates an anagram (out can mean wrong or inaccurate).
'i' put next to 'hand' is 'ihand'.
'ihand' is an anagram of 'DINAH'.
'can' is the link.
(Other definitions for dinah that I've seen before include "Washington perhaps" , "_____ 15+22, singer" .)