She can make Ian ill! (6)
I believe the answer is:
lilian
'she' is the definition.
'make ian ill' is the wordplay.
'make' is an anagram indicator.
'ian'+'ill'='ianill'
'ianill' with letters rearranged gives 'LILIAN'.
'can' acts as a link.
(Another definition for lilian that I've seen is " girl".)
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