She gets Annie no end upset! (4)
I believe the answer is:
Here is my best explanation:
'she' is the definition.
'annie no end upset' is the wordplay.
'no end' means to remove the last letter.
'upset' indicates anagramming the letters.
'annie' with its final letter removed is 'anni'.
'anni' anagrammed gives 'NINA'.
'gets' is the link.
(Other definitions for nina that I've seen before include "One of Columbus's ships in 1492; girl's name", "Name", "girl", "hidden crossword message", "Girl", "- Simone, US singer", "Al Hirschfeld's 'hidden' daughter" and "- - Simone, 1933-2003, singer".)