She gets Annie no end upset! (4)
I believe the answer is:
Here is my best explanation:
'she' is the definition.
'annie no end upset' is the subsidiary indication.
'no end' means to remove the last letter.
'upset' is an anagram indicator.
'annie' with its last letter taken off is 'anni'.
'anni' with letters rearranged gives 'nina'.
'gets' is the link.
(Other definitions for nina that I've seen before include "- - Simone, 1933-2003, singer", "- Simone, US singer", "One of Columbus's ships in 1492; girl's name", "Al Hirschfeld's 'hidden' daughter" and "Girl".)