She has children - 1000 not the same! (6)
I believe the answer is:
mother
'she has children' is the definition.
I can't judge whether this defines the answer.
'1000 not the same' is the wordplay.
'1000' becomes 'M' (roman numeral).
'not the same' becomes 'other' (I've seen this before).
'm'+'other'='MOTHER'
Can you help me to learn more?
(Other definitions for mother that I've seen before include "Mum" , "- - 7 across, pantomime" , "One who pours the tea?" , "She gives birth" , "Parent to her Tom, oddly" .)