She possibly takes one in hand (5)
I believe the answer is:
dinah
'she' is the definition.
'takes one in hand' is the wordplay.
I cannot quite understand how this works, but
'one' could be 'i' (Roman numeral) and 'i' is present in the answer.
an anagram of 'hand' is 'dnah' which is present in the remaining letters.
This accounts for all the letters.
This may be the basis of the clue (or it may be nonsense).
'possibly' is the link.
Can you help me to learn more?
(Other definitions for dinah that I've seen before include "_____ 15+22, singer" , "Washington perhaps" .)