She'll show anger with heartless nurse (5)
I believe the answer is:
irene
'she'll' is the definition.
I can't judge whether this definition defines the answer.
'anger with heartless nurse' is the wordplay.
'anger' becomes 'ire' (ire is intense rage).
'with' means one lot of letters go next to another.
'heartless' suggests removing the centre.
'nurse' with its middle removed is 'ne'.
'ire'+'ne'='IRENE'
'show' is the link.
Can you help me to learn more?
(Other definitions for irene that I've seen before include "Girl of peace" , "Greek godess of peace" , "woman" , "US actress, -- Dunne" , "- - Worth, actress" .)