Shut up and run away with loyal wife (8)
I believe the answer is:
penelope
'loyal wife' is the definition.
'penelope' can be an answer for 'wife' (I have seen 'Wife of Odysseus' mean 'penelope' so perhaps 'wife' could also mean 'penelope'). I am unsure of the 'loyal' bit.
'shut up and run away' is the wordplay.
'shut up' becomes 'pen' (pen can mean to shut in or enclose).
'and' is a charade indicator (letters next to each other).
'run away' becomes 'elope' (I've seen this in another clue).
'pen'+'elope'='PENELOPE'
'with' is the link.
Can you help me to learn more?
(Other definitions for penelope that I've seen before include "The wife who waited for years for Odysseus" , "Odysseus's wife" , "lady" , "Wife of Odysseus or Ulysses" , "Woman" .)