Signora's extremities need large shoe (6)
I believe the answer is:
sandal
'shoe' is the definition.
(sandal is a kind of shoe)
I can't explain the remainder of the clue.
(Other definitions for sandal that I've seen before include "Light strapped shoe" , "Item of footwear" , "One can go on foot" , "An open shoe for summer" , "Light footwear" .)