Spirit with a girl (6)
I believe the answer is:
angela
'girl' is the definition.
(I know that Angela is a female given name)
'spirit with a' is the wordplay.
'spirit' becomes 'angel'.
'with' is a charade indicator (letters next to each other).
'angel'+'a'='ANGELA'
(Other definitions for angela that I've seen before include "girl" , "woman" , "- Gheorghiu, Romanian soprano" , "Girl's name" , "- Carter, English writer" .)