Strange unease about very wide roads (7)
I believe the answer is:
avenues
'wide roads' is the definition.
(an avenue is a wide road)
'strange unease about very' is the wordplay.
'strange' indicates anagramming the letters.
'about' is an insertion indicator.
'very' becomes 'v' (common abbreviation).
'unease' is an anagram of 'aenues'.
'aenues' placed around 'v' is 'AVENUES'.
(Other definitions for avenues that I've seen before include "City streets or methods of approach" , "Approaches" , "Tree-lined roads" .)