Take too much flipping dope, ecstasy and port (6)
I believe the answer is:
odessa
'port' is the definition.
(Odessa is a Ukrainian port)
'take too much flipping dope ecstasy' is the wordplay.
'take too much' becomes 'OD' (overdose).
'flipping' shows that the letters should be reversed in order.
'dope' becomes 'ass' (both can mean a stupid person).
'ecstasy' becomes 'E' (informal term for the drug).
'ass'+'e'='asse'
'asse' in reverse letter order is 'essa'.
'od'+'essa'='ODESSA'
'and' acts as a link.
(Other definitions for odessa that I've seen before include "Port city on the Black Sea" , "Do seas come into Ukrainian city?" , "Port city of Ukraine" , "Black Sea location" , "Ukrainian Black Sea port" .)