The main point of registration (4)
I believe the answer is:
gist
'the main point' is the definition.
(the main point or meaning of something)
'of registration' is the wordplay.
'of' indicates a hidden word.
'GIST' can be found hidden inside 'registration'.
(Other definitions for gist that I've seen before include "Main point of the matter" , "Real point or substance" , "Main points" , "Drift" , "Core meaning" .)