Thus might guy get endless skin problem (5)
I believe the answer is:
mange
'skin problem' is the definition.
(I've seen this in another clue)
'thus might guy get endless' is the wordplay.
I cannot quite understand how this works, but
'guy' could be 'man' (guy can informally mean a man) and 'man' is found within the answer.
The remaining letters 'ge' is a valid word which might be clued in a way I don't see.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for mange that I've seen before include "Itchy disease in dogs, etc" , "Disease affecting dog hair" , "Skin disease affecting hairy animals" , "Domestic animals may find it very irritating" , "Animal's skin disease causing loss of hair" .)