To run out a twisted hose is a desperate thing to do! (4,4)
I believe the answer is:
lose hope
'a desperate thing to do' is the definition.
I can't judge whether this defines the answer.
'to run out a twisted hose' is the wordplay.
'to run' becomes 'lope' (loping is a kind of running).
'out' means one lot of letters goes inside another.
'a twisted' indicates anagramming the letters.
'hose' is an anagram of 'seho'.
'lope' going around 'seho' is 'LOSE HOPE'.
'is' acts as a link.
Can you help me to learn more?
(Other definitions for lose hope that I've seen before include "Become pessimistic" , "Despair" .)