Totally out of control (4)
I believe the answer is:
amok
'totally out of control' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for amok that I've seen before include "A state of murderous frenzy" , "'Wildly, without self-control (4)'" , "In an uncontrolled, often violent, way" , "Going mad" , "crazy" .)