Transport to hotel with infant, one with large eyes (8)
I believe the answer is:
bushbaby
'one with large eyes' is the definition.
(large-eyed animal)
'transport to hotel with infant' is the wordplay.
'transport' becomes 'bus' (busing is a kind of transporting).
'to hotel' becomes 'h' (phonetic alphabet: alpha, bravo, charlie etc.).
'with' means one lot of letters go next to another.
'infant' becomes 'baby' (synonyms).
'bus'+'h'+'baby'='BUSHBABY'
(Other definitions for bushbaby that I've seen before include "Nocturnal African lemur (closely related to one of two US presidents?)" , "Small, nocturnal, tree-dwelling primate of Africa with large eyes" , "Small African lemur, like shrubbery infant" , "African lemur-like primate (closely related to one of two US presidents?)" , "Big-eyed, long-tailed African primate" .)