Trash from museum is filling luggage on vacation (9)
I believe the answer is:
vandalise
'trash' is the definition.
(I've seen this before)
'museum is filling luggage on vacation' is the wordplay.
'museum' becomes 'vanda' (Victoria and Albert Museum).
'filling' means one lot of letters goes inside another.
'on vacation' means to remove the middle letters (after the inside letters have vacated the word).
'luggage' with its centre removed is 'le'.
'is' put into 'le' is 'lise'.
'vanda'+'lise'='VANDALISE'
'from' is the link.
(Other definitions for vandalise that I've seen before include "trash" , "Inflict malicious damage" , "Wreck" , "Deliberately damage" , "Destroy" .)