Trouble repulsed in Lyon, naturally (5)
I believe the answer is:
annoy
'trouble' is the definition.
(thesaurus)
'repulsed in lyon naturally' is the wordplay.
'repulsed' shows that the letters should be reversed in order.
'in' indicates a hidden word.
'yonna' is hidden within 'lyon naturally'.
'yonna' backwards is 'ANNOY'.
(Other definitions for annoy that I've seen before include "Anger" , "hack off" , "eat" , "Exasperate" , "get angry" .)