Troubles with automobiles out East (5)
I believe the answer is:
cares
'troubles' is the definition.
(I've seen this in another clue)
'automobiles out east' is the wordplay.
'automobiles' becomes 'cars' ('car' can be a synonym of 'automobile').
'out' is an insertion indicator.
'east' becomes 'e' (synonyms).
'cars' placed around 'e' is 'CARES'.
'with' is the link.
(Other definitions for cares that I've seen before include "Worries, anxieties" , "Has concerns or interest" , "Minds" , "Feels interest or concern" .)