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Turning practically senile with hepatic disorder (12)

Ross

I believe the answer is:

encephalitis

'disorder' is the definition.
(encephalitis is a kind of disease)

'turning practically senile with hepatic' is the wordplay.
'turning' is an anagram indicator.
'practically' means to remove the last letter.
'with' says to put letters next to each other.
'senile' with its last letter taken away is 'senil'.
'senil' after 'hepatic' is 'hepaticsenil'.
'hepaticsenil' is an anagram of 'ENCEPHALITIS'.

I've seen this clue in The Telegraph.
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