Two women contain large problem (7)
I believe the answer is:
dilemma
'problem' is the definition.
(a dilemma is a problem)
'two women contain large' is the wordplay.
'two women' can mean two substitutions for 'woman'.
'woman' becomes 'di' (short for Diana).
'woman' becomes 'emma' ().
'contain' indicates putting letters inside.
'large' becomes 'L' (eg in clothes sizes).
'di'+'emma'='diemma'
'diemma' enclosing 'l' is 'DILEMMA'.
(Other definitions for dilemma that I've seen before include "I lammed away to find perplexing situation" , "Catch-22" , "Difficult-choice situation" , "Situation requiring a choice between (equally unpleasant) options" , "Difficult decision" .)