Unattached ladies meet heartless swine (5)
I believe the answer is:
loose
'unattached' is the definition.
(I've seen this before)
'ladies meet heartless swine' is the wordplay.
'ladies' becomes 'loo' ('the ladies' is a type of loo or toilet).
'meet' is a charade indicator (letters next to each other).
'heartless' says to hollow out the word (remove centre letters).
'swine' with its centre removed is 'se'.
'loo'+'se'='LOOSE'
(Other definitions for loose that I've seen before include "Relaxed; not tethered" , "Water heater" , "Not fixed; inexact" , "Release" , "Vague -- insecure" .)