Unconventional line-up like Wolves (6)
I believe the answer is:
lupine
'like wolves' is the definition.
(I've seen this before)
'unconventional line-up' is the wordplay.
'unconventional' is an anagram indicator.
'line-up' becomes 'lineup' (synonyms).
'lineup' with letters rearranged gives 'LUPINE'.
(Other definitions for lupine that I've seen before include "ike wolves" , "like a wild animal" , "Like a wolf" , "Wolfish" , "Of or like wolves" .)