Unhappy keeping clever lady (12)
I believe the answer is:
bluestocking
'clever lady' is the definition.
The answer and definition can be both people as well as being singular nouns.
Perhaps you can see an association between them that I don't see?
'unhappy keeping' is the wordplay.
'unhappy' becomes 'blue' (blue can mean sad or miserable).
'keeping' becomes 'stocking'.
'blue'+'stocking'='BLUESTOCKING'
Can you help me to learn more?
(Other definitions for bluestocking that I've seen before include "Dated term for an intellectual woman" , "scholarly woman" , "Female scholar" , "woman of intelligence" .)