Upset on account of change (8)
I believe the answer is:
overturn
'upset' is the definition.
(I've seen this before)
'on account of change' is the wordplay.
'on account of' becomes 'over'.
'change' becomes 'turn' (turn is a kind of change**).
'over'+'turn'='OVERTURN'
(Other definitions for overturn that I've seen before include "Reverse (legal ruling)" , "Reverse, rescind," , "Capsize - invalidate" , "Empty out" , "Reverse; upend" .)