Very old affliction (4)
I believe the answer is:
sore
I believe this clue is a double definition.
'very old' is the first definition.
(archaic or old word for very)
'affliction' is the second definition.
(sore is a kind of health problem)
(Other definitions for sore that I've seen before include "Rose (anag.)" , "Painful - resentful" , "Raw or annoyed" , "Feeling pain or informally angry" , "Tender spot" .)