Virginia gets sick of the house (5)
I believe the answer is:
villa
'house' is the definition.
(villa is a kind of house)
'virginia gets sick' is the wordplay.
'virginia' becomes 'va' (US state abbreviation).
'gets' means one lot of letters goes inside another (gets can mean captures or absorbs).
'sick' becomes 'ill' (synonyms).
'va' enclosing 'ill' is 'VILLA'.
'of the' is the link.
(Other definitions for villa that I've seen before include "Classical country house" , "Rented holiday home" , "Ancient Roman's country house" , "Type of house" , "SECOND PART OF 8" .)