Vocation; rush (6)
I believe the answer is:
career
I believe this is a double definition.
'vocation' is the first definition.
(synonyms)
'rush' is the second definition.
(career can mean to run or move out of control)
(Other definitions for career that I've seen before include "Lifetime occupation" , "Life (in terms of work etc)" , "Life's occupation" , "Run headlong at high speed" , "Run; calling" .)