Way cathedral city set up fashion (5)
I believe the answer is:
style
'fashion' is the definition.
(I know that fashion can be written as style)
'way cathedral city set up' is the wordplay.
'way' becomes 'st' (abbreviation for street).
'cathedral city' becomes 'ely' (English city with a cathedral).
'set up' shows that the letters should be reversed in order (in a down clue, letters go up).
'ely' back-to-front is 'yle'.
'st'+'yle'='STYLE'
(Other definitions for style that I've seen before include "Elan" , "Designate" , "With 1a [OLD], type" , "Pointed pen" , "name" .)