We ran off with small reply (6)
I believe the answer is:
answer
'reply' is the definition.
(synonyms)
'we ran off with small' is the wordplay.
'off with' indicates anagramming the letters.
'small' becomes 's' (abbreviation - e.g. clothes size).
'we'+'ran'='weran'
'weran' mixed up with 's' can make 'ANSWER'.
(Other definitions for answer that I've seen before include "'Daisy, Daisy, give me your ...... do'" , "Retort" , "Acknowledge" , "Response to a question" , "Reaction to a question" .)