Well-off male like Polyphemus losing heart (7)
I believe the answer is:
moneyed
'well-off' is the definition.
(I've seen this before)
'male like polyphemus losing heart' is the wordplay.
I cannot quite understand how this works, but
'male' could be 'ed' (man's name) and 'ed' is present in the answer.
'like' could be 'y' (similar in meaning) and 'y' is located in the answer.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for moneyed that I've seen before include "Mo' needy? (Anag)" , "flush" , "Having means" , "Well-heeled" , "rolling in it" .)