What doctor seeks, buttonholing one famous scientist (5)
I believe the answer is:
curie
'famous scientist' is the definition.
(I've seen this in another clue)
'what doctor seeks buttonholing one' is the wordplay.
I cannot really see how this works, but
'one' could be 'i' (Roman numeral) and 'i' is located in the answer.
'doctor' could be 'cure' (I've seen this in another clue) and 'cure' is found within the remaining letters.
No letters remain.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for curie that I've seen before include "Marie --, French physicist" , "Scientist" , "Marie ---, found radium" , "Nobel Prize winner for physics (1903) and chemistry (1911), d. 1934" , "Unit of radioactivity" .)