Wife comes up about to be angry (5)
I believe the answer is:
storm
'be angry' is the definition.
(thesaurus)
'wife comes up about to' is the wordplay.
'wife' becomes 'mrs' (Mrs is an example).
'comes up' says the letters should be written in reverse (in a down clue, letters go up).
'about' means one lot of letters goes inside another.
'mrs' written backwards gives 'srm'.
'srm' enclosing 'to' is 'STORM'.
(Other definitions for storm that I've seen before include "Gale, tempest" , "Very unfavourable climate" , "Attack and capture (a place)" , "Furore" , "= Gale force 10" .)