Wipe out lots of times out East (5)
I believe the answer is:
erase
'wipe out lots' is the definition.
'erase' can be an answer for 'wipe' (I've seen this in another clue). I am not sure about the 'out lots' bit.
'times out east' is the wordplay.
'times' becomes 'eras' (era is a kind of time).
'out east' becomes 'e' (abbreviation. I am not sure about the 'out' bit.).
'eras'+'e'='ERASE'
'of' is the link.
Can you help me to learn more?
(Other definitions for erase that I've seen before include "Remove recorded material" , "Eliminate" , "Remove permanently" , "Remove from memory" , "Remove, wipe out" .)